miR-135a Suppresses Calcification in Senescent VSMCs by Regulating KLF4/STAT3 Pathway

@inproceedings{Lin2016miR135aSC,
  title={miR-135a Suppresses Calcification in Senescent VSMCs by Regulating KLF4/STAT3 Pathway},
  author={Lin Lin and Yue He and Bei-li Xi and Hong-chao Zheng and Qian Chen and Jun Li and Ying Hu and Ming-Hao Ye and Ping Chen and Yi Qu},
  booktitle={Current vascular pharmacology},
  year={2016}
}
Cellular function phenotype is regulated by various microRNAs (miRs), including miR-135a. However, how miR-135a is involved in the calcification in senescent vascular smooth muscle cells (VSMCs) is not clear yet. In the present study, we first identified the significantly altered miRNAs in VSMCs, then performed consecutive passage culture of VSMCs and analyzed the expression of miR- 135a and calcification genes in the senescent phase. Next, the effects of the miR-135a inhibition on… CONTINUE READING