miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction

@article{Izarra2014miR133aET,
  title={miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction},
  author={A. Izarra and I. Moscoso and Elif Levent and S. Cañón and I. Cerrada and A. D{\'i}ez-Juan and Vanessa Blanca and I. N{\'u}{\~n}ez-Gil and {\'I}{\~n}igo Valiente and A. Ru{\'i}z-Sauri and P. Sep{\'u}lveda and M. Tiburcy and W. Zimmermann and A. Bernad},
  journal={Stem Cell Reports},
  year={2014},
  volume={3},
  pages={1029 - 1042}
}
Summary miR-133a and miR-1 are known as muscle-specific microRNAs that are involved in cardiac development and pathophysiology. We have shown that both miR-1 and miR-133a are early and progressively upregulated during in vitro cardiac differentiation of adult cardiac progenitor cells (CPCs), but only miR-133a expression was enhanced under in vitro oxidative stress. miR-1 was demonstrated to favor differentiation of CPCs, whereas miR-133a overexpression protected CPCs against cell death… Expand
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