miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity

@inproceedings{Remenyi2013miR132212KM,
  title={miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity},
  author={Judit Remenyi and Mirjam van den Bosch and Oleg Palygin and Rajen B. Mistry and Colin S McKenzie and Andrew Macdonald and Gyorgy Hutvagner and J Simon C Arthur and Bruno G Frenguelli and Yuriy Pankratov},
  booktitle={PloS one},
  year={2013}
}
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describe here the generation and initial characterisation of a miR-132/212 double knockout mouse. These mice were viable and fertile with no overt adverse phenotype. Analysis of innate immune responses, including TLR-induced cytokine production and IFNβ induction in response to viral infection of primary… CONTINUE READING
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