miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity

  title={miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity},
  author={Judit Remenyi and Mirjam W. M. van den Bosch and O. Palygin and Rajen B. Mistry and C. McKenzie and A. Macdonald and G. Hutvagner and J. S. Arthur and B. Frenguelli and Y. Pankratov},
  journal={PLoS ONE},
  • Judit Remenyi, Mirjam W. M. van den Bosch, +7 authors Y. Pankratov
  • Published 2013
  • Medicine, Biology
  • PLoS ONE
  • miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describe here the generation and initial characterisation of a miR-132/212 double knockout mouse. These mice were viable and fertile with no overt adverse phenotype. Analysis of innate immune responses, including TLR-induced cytokine production and IFNβ induction in response to viral infection of primary… CONTINUE READING
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