miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis

@article{Zhang2013miR126AM,
  title={miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis},
  author={Yun Zhang and Pengyuan Y. Yang and Tao Sun and Dong Li and Xin Xu and Yaocheng Rui and Chaoran Li and Mengyang Chong and Toni Ibrahim and Laura Mercatali and Dino Amadori and Xincheng Lu and Dong Xie and Qi-jing Li and Xiao Fan Wang},
  journal={Nature Cell Biology},
  year={2013},
  volume={15},
  pages={284-294}
}
The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance. We report here that miR-126/miR-126*, a microRNA pair derived from a single precursor, independently suppress the sequential recruitment of mesenchymal stem cells and inflammatory monocytes into the tumour stroma to inhibit lung metastasis by breast… CONTINUE READING
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