miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

  title={miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells},
  author={Eric R. Lechman and Bernhard Gentner and Stanley W. K. Ng and Erwin Marten Schoof and Peter van Galen and James A. Kennedy and Silvia Nucera and Fabio Ciceri and Kerstin B. Kaufmann and Naoya Takayama and Stephanie M. Dobson and Aaron Trotman-Grant and Gabriela Krivdova and Janneke Elzinga and Amanda Mitchell and Bj{\"o}rn Nilsson and Karin G. Hermans and Kolja Eppert and Ren{\'e} Marke and Ruth Isserlin and V{\'e}ronique Voisin and Gary D. Bader and Peter W. Zandstra and Todd R. Golub and Benjamin L. Ebert and Jun Lu and Mark D Minden and Jean C Y Wang and Luigi Naldini and John E Dick},
  booktitle={Cancer cell},
To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent… CONTINUE READING
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