miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival.

Abstract

Previously, we identified miR-125b as a key regulator of the undifferentiated state of hair follicle stem cells. Here, we show that in both mice and humans, miR-125b is abundantly expressed, particularly at early stages of malignant progression to squamous cell carcinoma (SCC), the second most prevalent cancer worldwide. Moreover, when elevated in normal… (More)
DOI: 10.1101/gad.248377.114

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