miR-125b-1 is repressed by histone modifications in breast cancer cell lines

Abstract

PURPOSE Downregulation of miR-125b-1 is associated with poor prognosis in breast cancer patients. In this work we investigated the effect of histone modifications on the regulation of this gene promoter. METHODS AND RESULTS We evaluated the enrichment of two histone modifications involved in gene repression, H3K9me3 and H3K27me3, on the miR-125b-1… (More)
DOI: 10.1186/s40064-016-2475-z

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