miR-125 potentiates early neural specification of human embryonic stem cells.

@article{Boissart2012miR125PE,
  title={miR-125 potentiates early neural specification of human embryonic stem cells.},
  author={Claire Boissart and Xavier Nissan and Karine Giraud-Triboult and Marc Peschanski and Alexandra Benchoua},
  journal={Development},
  year={2012},
  volume={139 7},
  pages={
          1247-57
        }
}
The role of microRNAs (miRNAs) as coordinators of stem cell fate has emerged over the last decade. We have used human embryonic stem cells to identify miRNAs involved in neural lineage commitment induced by the inhibition of TGFβ-like molecule-mediated pathways. Among several candidate miRNAs expressed in the fetal brain, the two isoforms of miR-125 alone were detected in a time window compatible with a role in neural commitment in vitro. Functional analysis indicated that miR-125 isoforms were… CONTINUE READING

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