miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death.

Abstract

The MUC1 oncoprotein is aberrantly overexpressed in human carcinomas and hematologic malignancies. Micro-RNAs (miRNAs) have been implicated in the suppression and induction of oncogenesis. The present studies demonstrate that the MUC1 mRNA 3' untranslated region (3'UTR) contains a highly conserved motif for binding of a novel miRNA, miR-1226, that has no… (More)

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Cite this paper

@article{Jin2010miR1226TE, title={miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death.}, author={Caining Jin and Hasan N Rajabi and Donald Kufe}, journal={International journal of oncology}, year={2010}, volume={37 1}, pages={61-9} }