miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease.

@article{Chen2013miR122TN,
  title={miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease.},
  author={Yu Chen and Cheng-xiao Wang and Ying Liu and Liwei Tang and Mingxia Zheng and Chundi Xu and Jian Song and Xiaochun Meng},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={438 1},
  pages={133-9}
}
Crohn's disease (CD) is one of the two major types of inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors. Recently, miR-122 was found to be deregulated in association with CD progression. However, the underlying molecular mechanisms remain unclear. In the present study, the gene nucleotide-binding oligomerization domain 2 (NOD2/CARD15), which is strongly associated with susceptibility to CD, was identified as a functional target of miR-122. MiR-122… CONTINUE READING

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