miR-122 regulates hepatic lipid metabolism and tumor suppression.


In this issue of JCI, two independent groups describe the effects of germline and liver-specific deletion of Mir122a, the predominant liver miRNA. Their findings reveal a critical role for miR-122 in fat and cholesterol metabolism but suggest that other metabolic actions of the liver are independent of miR-122. Knockout mice also displayed hepatic inflammation, fibrosis, and a high incidence of hepatocellular carcinoma, suggesting that miR-122 has a tumor suppressor role in hepatocytes.

DOI: 10.1172/JCI63966

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@article{Wen2012miR122RH, title={miR-122 regulates hepatic lipid metabolism and tumor suppression.}, author={Jessica W. Wen and Joshua R Friedman}, journal={The Journal of clinical investigation}, year={2012}, volume={122 8}, pages={2773-6} }