miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV.

@article{Qiu2010miR122inducedDO,
  title={miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV.},
  author={Lipeng Qiu and Hongxia Fan and Wensong Jin and Bao Hui Zhao and Yanzhong Wang and Yakun Ju and Lizhao Chen and Yu Chen and Zhong-ping Duan and Songdong Meng},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={398 4},
  pages={771-7}
}
As the most abundant liver-specific microRNA (miRNA), miR-122 has been extensively studied for its role in the regulation of lipid metabolism, hepatocarcinogenesis and hepatitis C virus (HCV) replication, but little is known regarding its role in the replication of Hepatitis B virus (HBV), a highly prevalent hepatotropic virus that can cause life-threatening complications. In this study we examined the effects of antisense inhibition of miR-122 and transfection of a miR-122 mimic on HBV… CONTINUE READING