miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma

@inproceedings{Liu2014miR122TP,
  title={miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma},
  author={Angela M. Liu and Zhi Xu and Felix H. Shek and K W Wong and Nikki Pui-yue Lee and Ronnie Tung-ping Poon and Jinfei Chen and John Moon-Ching Luk},
  booktitle={PloS one},
  year={2014}
}
In contrast to normal differentiated cells that depend on mitochondrial oxidative phosphorylation for energy production, cancer cells have evolved to utilize aerobic glycolysis (Warburg's effect), with benefit of providing intermediates for biomass production. MicroRNA-122 (miR-122) is highly expressed in normal liver tissue regulating a wide variety of biological processes including cellular metabolism, but is reduced in hepatocellular carcinoma (HCC). Overexpression of miR-122 was shown to… CONTINUE READING