miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours

  title={miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours},
  author={Francesca Biagioni and Noa Bossel Ben-Moshe and Giulia Fontemaggi and Valeria Canu and Federica Mori and Barbara Antoniani and Anna Di Benedetto and Raffaela Santoro and Sabrina Germoni and Fernanda Gabriella De Angelis and Anna Cambria and Roi Avraham and Giuseppe Grasso and Sabrina Strano and Paola Muti and Marcella Mottolese and Yosef Yarden and Eytan Domany and Giovanni Blandino},
  booktitle={EMBO molecular medicine},
Deregulated proliferation is a hallmark of cancer cells. Here, we show that microRNA-10b* is a master regulator of breast cancer cell proliferation and is downregulated in tumoural samples versus matched peritumoural counterparts. Two canonical CpG islands (5 kb) upstream from the precursor sequence are hypermethylated in the analysed breast cancer tissues. Ectopic delivery of synthetic microRNA-10b* in breast cancer cell lines or into xenograft mouse breast tumours inhibits cell proliferation… CONTINUE READING
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