miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes.

@article{Shan2010miR1miR206RH,
  title={miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes.},
  author={Z. R. Shan and Qiu-xiong Lin and Chun-yu Deng and Jie-ning Zhu and Li-Ping Mai and Ju-li Liu and Yong-heng Fu and Xiao-ying Liu and Yang-xin Li and Y Jonathan Zhang and Shu-guang Lin and Xi-Yong Yu},
  journal={FEBS letters},
  year={2010},
  volume={584 16},
  pages={3592-600}
}
Hsp60 is an important component of defense mechanisms against diabetic myocardial injury; however, the cause of Hsp60 reduction in the diabetic myocardium remains unknown. After stimulation of cardiomyocytes with high glucose in vivo and in vitro, significant up-regulation of miR-1/miR-206 and post-transcriptional modulation of Hsp 60 were observed. Serum response factor (SRF) and the MEK1/2 pathway were involved in miR-1 and miR-206 expression in cardiomyocytes. miR-1 and miR-206 regulated… CONTINUE READING

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