meta-Iodobenzylguanidine, an Inhibitor of Arginine-Dependent Mono(ADP-ribosyl)ation, Prevents Neointimal Hyperplasia

  title={meta-Iodobenzylguanidine, an Inhibitor of Arginine-Dependent Mono(ADP-ribosyl)ation, Prevents Neointimal Hyperplasia},
  author={L. Yau and P. Moln{\'a}r and M. Moon and S. Buhay and J. Werner and K. Molnar and L. Saward and D. D. Del Rizzo and P. Zahradka},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={717 - 724}
  • L. Yau, P. Molnár, +6 authors P. Zahradka
  • Published 2008
  • Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • The association of ADP-ribosylation with cell proliferation and ischemia-reperfusion injury suggests that it may be a suitable target for therapeutic control of revascularization-induced injury. The purpose of this study was to investigate the inhibitory actions of ADP-ribosylation inhibitors on restenosis. In organ culture, the poly(ADP-ribose) polymerase (PARP) inhibitor 3,4-dihydro-5-methylisoquinolinone (PD128763) was unable to prevent neointimal hyperplasia, whereas the arginine-dependent… CONTINUE READING
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