meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye.

@article{Bessa2008meis1RC,
  title={meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye.},
  author={Jos{\'e} Elievam Bessa and Maria J. Tavares and Joana Lima Santos and Hiroshi Kikuta and Mary Laplante and Thomas Becker and Jos{\'e} Luis G{\'o}mez-Skarmeta and Fernando Casares},
  journal={Development},
  year={2008},
  volume={135 5},
  pages={799-803}
}
During eye development, retinal progenitors are drawn from a multipotent, proliferative cell population. In Drosophila the maintenance of this cell population requires the function of the TALE-homeodomain transcription factor Hth, although its mechanisms of action are still unknown. Here we investigate whether members of the Meis gene family, the vertebrate homologs of hth, are also involved in early stages of eye development in the zebrafish. We show that meis1 is initially expressed… CONTINUE READING

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