megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

  title={megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering},
  author={Sandrine J. S. Boissel and Jordan Jarjour and Alexander Astrakhan and Andrew C Adey and Agn{\`e}s Gouble and Philippe Duchateau and Jay Shendure and Barry L. Stoddard and Michael T. Certo and David P. Baker and Andrew M Scharenberg},
  booktitle={Nucleic acids research},
Rare-cleaving endonucleases have emerged as important tools for making targeted genome modifications. While multiple platforms are now available to generate reagents for research applications, each existing platform has significant limitations in one or more of three key properties necessary for therapeutic application: efficiency of cleavage at the desired target site, specificity of cleavage (i.e. rate of cleavage at 'off-target' sites), and efficient/facile means for delivery to desired… CONTINUE READING
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