• Biology, Medicine
  • Published in Development 1997

meander tail acts intrinsic to granule cell precursors to disrupt cerebellar development: analysis of meander tail chimeric mice.

@article{Hamre1997meanderTA,
  title={meander tail acts intrinsic to granule cell precursors to disrupt cerebellar development: analysis of meander tail chimeric mice.},
  author={Kristin Hamre and Daniel Goldowitz},
  journal={Development},
  year={1997},
  volume={124 21},
  pages={
          4201-12
        }
}
The murine mutation meander tail (gene symbol: mea) causes a near-total depletion of granule cells in the anterior lobe of the cerebellum, as well as aberrantly located Purkinje cells with misoriented dendrites and radial glia with stunted processes. Whether one, two or all three of these cell types is the primary cellular target(s) of the mutant gene is unknown. This issue is addressed by examining cerebella from adult chimeras in which both the genotype and phenotype of individual cells are… CONTINUE READING

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