mdm2 expression is induced by wild type p53 activity.

@article{Barak1993mdm2EI,
  title={mdm2 expression is induced by wild type p53 activity.},
  author={Yoav Barak and T Juven and Rebecca Haffner and Moshe Oren},
  journal={The EMBO journal},
  year={1993},
  volume={12 2},
  pages={
          461-8
        }
}
We have recently characterized a 95 kDa protein, p95, which exhibits enhanced binding to temperature-sensitive p53 (ts-p53) when cells are shifted down to 32.5 degrees C, a temperature at which ts-p53 possesses wild-type (wt)-like activities. In the present study we show that p95 is a product of the mdm2 putative proto-oncogene. The enhanced complex formation of mdm2 with ts-p53 in cells maintained at 32.5 degrees C is due to an elevation in total mdm2 protein levels following the temperature… CONTINUE READING
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