mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.

@article{Chen1996mdm2IT,
  title={mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.},
  author={Jianxin Chen and Xiaofang Wu and Joseph K M Lin and Arnold J. Levine},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 5},
  pages={2445-52}
}
The mdm-2 gene encodes a 90-kDa polypeptide that binds specifically to the p53 tumor suppressor protein. This physical interaction results in the inhibition of the transcriptional functions of p53 (J. Chen, J. Lin, and A. J. Levine, Mol. Med. 1:142-152, 1995, and J. Momand, G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine, Cell 69:1237-1245, 1992). Experiments are described that demonstrate the ability of mdm-2 to abrogate both the p53-mediated cell cycle arrest and the apoptosis… CONTINUE READING
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