mda-7/IL-24: exploiting cancer's Achilles' heel.

  title={mda-7/IL-24: exploiting cancer's Achilles' heel.},
  author={Irina V. Lebedeva and Moira Sauane and Rahul V Gopalkrishnan and Devanand Sarkar and Zhao-zhong Su and Pankaj Gupta and John Nemunaitis and Casey Cunningham and Adly Yacoub and Paul Dent and Paul B Fisher},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={11 1},
The mda-7/IL-24 cDNA was isolated almost a decade ago in a screen for genes differentially upregulated following growth arrest and terminal differentiation of a human melanoma cell line employed as an in vitro cell differentiation model. The underlying rationale for the screen was that oncogenesis arises from a cellular dedifferentiation process culminating in uncontrolled proliferation and acquisition of invasive and metastatic potential. Identification of genes upregulated during the process… CONTINUE READING

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