mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.

@article{Dash2010mda7IL24AU,
  title={mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.},
  author={Rupesh Dash and Sujit K Bhutia and Belal M Azab and Zhao-zhong Su and Bridget A. Quinn and Timothy P Kegelmen and Swadesh Kumar Das and Keetae Kim and Seok-Geun Lee and Margaret A. Park and Adly Yacoub and Mohammed Rahmani and Luni Emdad and Igor P. Dmitriev and Xiang-Yang Wang and Devanand Sarkar and Steven Grant and Paul Dent and David T. Curiel and Paul B Fisher},
  journal={Cytokine & growth factor reviews},
  year={2010},
  volume={21 5},
  pages={381-91}
}
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture… CONTINUE READING

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