mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans

@article{Shen1988mab3,
  title={
 mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans},
  author={Michael M. Shen and Jonathan Hodgkin},
  journal={Cell},
  year={1988},
  volume={54},
  pages={1019-1031}
}
Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior.
TLDR
It is found that mab-3 transcription is directly regulated in the intestine by TRA-1A, providing a molecular link between the global regulatory pathway and terminal sexual differentiation.
Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family.
TLDR
The results support the hypothesis that DM domain genes derive from an ancestral male sexual regulator and suggest how regulation of sexual development has evolved in distinct ways in different phyla.
Selective lineage specification by mab-19 during Caenorhabditis elegans male peripheral sense organ development.
TLDR
Mab-19 may play a larger role in developmental regulation of hypodermal cell fate, including sensory ray development in males, after body morphology mutations, passage through the dauer stage, and heat or CdCl2 treatment suppressed mab- 19 male phenotypes.
dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans
TLDR
Results reveal a regulatory network for male tail morphogenesis in which dmd-3 and mab-3 together occupy the central node and indicate that an important conserved function of DM genes is to link the general sex determination hierarchy to specific effectors of differentiation and morphogenesis.
Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.
TLDR
Based on sequence, map position, and expression patterns, it is suggested that Dmrt1 is likely to play a role in vertebrate sexual development and therefore that DM domain genes may play a roles in sexual development in a wide range of phyla.
The mab-9 gene controls the fate of B, the major male-specific blast cell in the tail region of Caenorhabditis elegans.
TLDR
It is proposed that the fates of the four rectal cells are initially specified as two pairs and that the function of mab-9 in both sexes is to differentiate the posterior member of each pair from its anterior neighbor.
Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms.
TLDR
This work shows that MAB-3, like the DSX proteins, is a direct regulator of yolk protein gene transcription, the first direct link between the sex determination regulatory pathway and sex-specific structural genes in C. elegans, suggesting that nematodes and insects use at least some of the same mechanisms to control sexual development.
Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.
TLDR
It is shown that murine Dmrt1 is essential for postnatal testis differentiation, with mutant phenotypes similar to those caused by human chromosome 9p deletions that remove the gene.
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