mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans

 mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans},
  author={Michael M. Shen and Jonathan Hodgkin},
Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior.
It is found that mab-3 transcription is directly regulated in the intestine by TRA-1A, providing a molecular link between the global regulatory pathway and terminal sexual differentiation.
Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family.
The results support the hypothesis that DM domain genes derive from an ancestral male sexual regulator and suggest how regulation of sexual development has evolved in distinct ways in different phyla.
Selective lineage specification by mab-19 during Caenorhabditis elegans male peripheral sense organ development.
Mab-19 may play a larger role in developmental regulation of hypodermal cell fate, including sensory ray development in males, after body morphology mutations, passage through the dauer stage, and heat or CdCl2 treatment suppressed mab- 19 male phenotypes.
dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans
Results reveal a regulatory network for male tail morphogenesis in which dmd-3 and mab-3 together occupy the central node and indicate that an important conserved function of DM genes is to link the general sex determination hierarchy to specific effectors of differentiation and morphogenesis.
Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.
Based on sequence, map position, and expression patterns, it is suggested that Dmrt1 is likely to play a role in vertebrate sexual development and therefore that DM domain genes may play a roles in sexual development in a wide range of phyla.
The mab-9 gene controls the fate of B, the major male-specific blast cell in the tail region of Caenorhabditis elegans.
It is proposed that the fates of the four rectal cells are initially specified as two pairs and that the function of mab-9 in both sexes is to differentiate the posterior member of each pair from its anterior neighbor.
Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms.
This work shows that MAB-3, like the DSX proteins, is a direct regulator of yolk protein gene transcription, the first direct link between the sex determination regulatory pathway and sex-specific structural genes in C. elegans, suggesting that nematodes and insects use at least some of the same mechanisms to control sexual development.
Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.
It is shown that murine Dmrt1 is essential for postnatal testis differentiation, with mutant phenotypes similar to those caused by human chromosome 9p deletions that remove the gene.


A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans.
The results suggest that the tra-1 gene has several roles in wild-type sexual development, and it is suggested that the function and the regulation of this gene must be complex.
An autosomal gene that affects X chromosome expression and sex determination in Caenorhabditis elegans.
It is proposed that dpy-21 regulates X chromosome expression and may be involved in interpreting X chromosome dose for the developmental decisions of both sex determination and dosage compensation.
More sex-determination mutants of Caenorhabditis elegans.
The epistatic relationships between tra and her genes are used to deduce a model for the action of these genes in controlling sex determination, and the her-2 mutation may result in constitutive expression of tra-1.
Two types of sex determination in a nematode
It is shown that stable mutant strains can be constructed in which sex is determined not by X-chromosome dosage but by the presence or absence of a single active gene.
Male Phenotypes and Mating Efficiency in CAENORHABDITIS ELEGANS.
Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnormalities of the specialized male copulatory organs.
Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster.
It is shown that the tra, tra-2 and dsx loci determine sex in a cell-autonomous manner and are major regulatory loci that control the batteries of genes necessary for the development of many, and perhaps all, secondary sexual characteristics.
Independent control elements that determine yolk protein gene expression in alternative Drosophila tissues.
The adjacent and divergently transcribed yp1 and yp2 genes of Drosophila were separated at a site that is 342 base pairs upstream of yp2 and 883 base pairs upstream of yp1. Each gene was separately