mTORC2 dictates Warburg effect and drug resistance

Abstract

Metabolic reprogramming, a prominent phenotype in cancer cells, is the adaptation to shifts in the usage of metabolites, including glucose, fatty acids, amino acids, and glutamine. The central feature of this adaptation lies in the fact that cancer cells undergo glycolysis even in the presence of ample oxygen, contrary to normal cells. This aerobic… (More)
DOI: 10.4161/cc.28377

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