mTORC1 links protein quality and quantity control by sensing chaperone availability.

  title={mTORC1 links protein quality and quantity control by sensing chaperone availability.},
  author={Shu-Bing Qian and Xingqian Zhang and Jun Sun and Jack R. Bennink and Jonathan W. Yewdell and C. G. Patterson},
  journal={The Journal of biological chemistry},
  volume={285 35},
Balanced protein synthesis and degradation are crucial for proper cellular function. Protein synthesis is tightly coupled to energy status and nutrient levels by the mammalian target of rapamycin complex 1 (mTORC1). Quality of newly synthesized polypeptides is maintained by the molecular chaperone and ubiquitin-proteasome systems. Little is known about how cells integrate information about the quantity and quality of translational products simultaneously. We demonstrate that cells distinguish… CONTINUE READING

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mTORC1 Links Protein Quality and Quantity Control

J. F. Morley, R. I. Morimoto
Biol. Cell 15, • 2004
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