mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Abstract

mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases including cancer, diabetes, and heart disease. However, the mechanisms that coordinate translation and energy metabolism in mammals remain largely unknown. The mechanistic/mammalian target of rapamycin… (More)
DOI: 10.1016/j.cmet.2013.10.001

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