mTORC1 and the regulation of skeletal muscle anabolism and mass.

  title={mTORC1 and the regulation of skeletal muscle anabolism and mass.},
  author={Olasunkanmi A. J. Adegoke and Abdikarim Abdullahi and Pegah Tavajohi-Fini},
  journal={Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme},
  volume={37 3},
The mass and integrity of skeletal muscle is vital to whole-body substrate metabolism and health. Indeed, defects in muscle metabolism and functions underlie or exacerbate diseases like diabetes, rheumatoid arthritis, and cancer. Physical activity and nutrition are the 2 most important environmental factors that can affect muscle health. At the molecular level, the mammalian target of rapamycin complex 1 (mTORC1) is a critical signalling complex that regulates muscle mass. In response to… CONTINUE READING
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