mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide
@article{Matsumoto2017mTORC1AM, title={mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide}, author={Akinobu Matsumoto and Alessandra Pasut and Masaki Matsumoto and Riu Yamashita and Jacqueline Fung and Emanuele Monteleone and Alan Saghatelian and Keiichi I. Nakayama and John Gerard Clohessy and Pier Paolo Pandolfi}, journal={Nature}, year={2017}, volume={541}, pages={228-232} }
Although long non-coding RNAs (lncRNAs) are non-protein-coding transcripts by definition, recent studies have shown that a fraction of putative small open reading frames within lncRNAs are translated. However, the biological significance of these hidden polypeptides is still unclear. Here we identify and functionally characterize a novel polypeptide encoded by the lncRNA LINC00961. This polypeptide is conserved between human and mouse, is localized to the late endosome/lysosome and interacts…
354 Citations
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A novel polypeptide is uncovered, which is encoded by the lncRNA LINC00961, and regulates amino acid dependent mTORC1 signaling, and is validated by a mass spectrometry based pipeline to identify lnc RNA translated ORFs.
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