mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

@article{Matsumoto2017mTORC1AM,
  title={mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide},
  author={Akinobu Matsumoto and Alessandra Pasut and Masaki Matsumoto and Riu Yamashita and Jacqueline Fung and Emanuele Monteleone and Alan Saghatelian and Keiichi I. Nakayama and John Gerard Clohessy and Pier Paolo Pandolfi},
  journal={Nature},
  year={2017},
  volume={541},
  pages={228-232}
}
Although long non-coding RNAs (lncRNAs) are non-protein-coding transcripts by definition, recent studies have shown that a fraction of putative small open reading frames within lncRNAs are translated. However, the biological significance of these hidden polypeptides is still unclear. Here we identify and functionally characterize a novel polypeptide encoded by the lncRNA LINC00961. This polypeptide is conserved between human and mouse, is localized to the late endosome/lysosome and interacts… 
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TLDR
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TLDR
The functional importance of a micropeptide-encoding RNA transcript in the vascular endothelium is described and dissected, and it is demonstrated that both the RNA and the peptide regulate endothelial biology.
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