mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.

@article{Inoki2011mTORC1AI,
  title={mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.},
  author={Ken Inoki and Hiroyuki Mori and Junying Wang and Tsukasa Suzuki and Sungki Hong and Sei Yoshida and Simone Monika Blattner and Tsuneo Ikenoue and Markus A R{\"u}egg and Michael N. Hall and D. J. Kwiatkowski and Maria P Rastaldi and Tobias B Huber and Matthias Kretzler and Lawrence B. Holzman and Roger C. Wiggins and Kun Liang Guan},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 6},
  pages={2181-96}
}
Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and type 2 diabetics. Podocyte dysfunction is postulated to be a critical event associated with proteinuria and glomerulosclerosis in glomerular diseases including DN. However, molecular mechanisms of podocyte dysfunction in the development of DN are not well understood. Here we have shown that activity of mTOR complex 1 (mTORC1), a kinase that senses nutrient availability, was enhanced in the podocytes of… CONTINUE READING
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