mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

@article{Tang2014mTORC1PD,
  title={mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases},
  author={Huibin Tang and Ken Inoki and Myung Chul Lee and Erika A Wright and Andy Khuong and Amanda Khuong and Sista Sugiarto and Matthew S Garner and Jihye Paik and Ronald A. Depinho and Daniel Goldman and Kun Liang Guan and Joseph B. Shrager},
  journal={Science Signaling},
  year={2014},
  volume={7},
  pages={ra18-ra18}
}
Skeletal muscle mass and function are regulated by motor innervation, and denervation results in muscle atrophy. The activity of mammalian target of rapamycin complex 1 (mTORC1) is substantially increased in denervated muscle, but its regulatory role in denervation-induced atrophy remains unclear. At early stages after denervation of skeletal muscle, a pathway involving class II histone deacetylases and the transcription factor myogenin mediates denervation-induced muscle atrophy. We found that… CONTINUE READING
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Insights from genetic models

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