mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.

Abstract

mTORC1 is a central signaling node in controlling cell growth, proliferation, and metabolism that is aberrantly activated in cancers and certain cancer-associated genetic disorders, such as tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis. However, while mTORC1-inhibitory compounds (rapamycin and rapalogs) attracted interest as… (More)
DOI: 10.1158/0008-5472.CAN-15-2629

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Cite this paper

@article{Li2016mTORC1DrivenTC, title={mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.}, author={Jing Li and Sejeong Shin and Yang Sun and Sang-oh Yoon and Chenggang Li and Erik Yuan Zhang and Jane Jie Yu and Jianming Zhang and John Blenis}, journal={Cancer research}, year={2016}, volume={76 16}, pages={4816-27} }