mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding.

@article{Delarue2018mTORC1CP,
  title={mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding.},
  author={Morgan Delarue and Gregory Brittingham and Stefan Pfeffer and Ivan V. Surovtsev and Sudarshan Pinglay and Kristopher J Kennedy and Miroslava Schaffer and Juan I Rodr{\'i}guez Guti{\'e}rrez and Deli Sang and Gregory Poterewicz and Jungrae Chung and J{\"u}rgen M Plitzko and Jay T. Groves and Christine Jacobs-Wagner and Benjamin D Engel and Liam Holt},
  journal={Cell},
  year={2018},
  volume={174 2},
  pages={
          338-349.e20
        }
}
Macromolecular crowding has a profound impact on reaction rates and the physical properties of the cell interior, but the mechanisms that regulate crowding are poorly understood. We developed genetically encoded multimeric nanoparticles (GEMs) to dissect these mechanisms. GEMs are homomultimeric scaffolds fused to a fluorescent protein that self-assemble into bright, stable particles of defined size and shape. By combining tracking of GEMs with genetic and pharmacological approaches, we… CONTINUE READING

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