mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression

@article{Chen2014mTORC12TB,
  title={mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression},
  author={Zhiguo Chen and Yuxiang Zhang and C Jia and Y Wang and P Lai and Xiwu Zhou and Qinhui Song and Jun Biao Lin and Zhiyong Ren and Qile Gao and Z Zhao and Hai Feng Zheng and Zi Wan and Tianyan Gao and Aizhi Zhao and Y Dai and X Bai},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={4548-4557}
}
Although epidemiological and preclinical studies have shown the preventative effects of n-3 polyunsaturated fatty acids (PUFAs) on breast cancer, inconsistencies still remain in the data and the underlying mechanisms remain unclear. In this study, we identified mammalian target of rapamycin (mTOR) signaling, which plays an essential role in cell proliferation and breast tumorigenesis, as a target of n-3 PUFAs. In breast cancer cell lines, n-3 PUFAs rapidly and efficiently suppress both mTOR… CONTINUE READING
22 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…