mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease.

@article{Belibi2011mTORC12AR,
  title={mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease.},
  author={Franck A Belibi and Kameswaran Ravichandran and Iram Zafar and Zhibin He and Charles Louis Edelstein},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={300 1},
  pages={F236-44}
}
Rapamycin slows disease progression in the male Han:SPRD (Cy/+) rat with polycystic kidney disease (PKD). The aim of this study was to determine the effect of rapamycin on PKD and the relative contributions of the proproliferative mammalian target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) in female Cy/+ rats. Female Cy/+ rats were treated with… CONTINUE READING