mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine

@article{Huang2018mTORSI,
  title={mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine},
  author={Shin-Han Huang and Wan-Rong Wu and Li-ming Lee and P. Huang and J C Chen},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2018},
  volume={86},
  pages={331-339}
}
Chronic psychostimulant treatment in rodents readily produces behavioral sensitization, which reflects altered brain function in response to repeated drug exposure. Numerous morphological and biochemical investigations implicate altered neural plasticity in striatal medium spiny neurons (MSNs) as an essential component in behavioral sensitization. The mammalian target of the rapamycin (mTOR) signaling pathway, a key regulator of synaptic neuroplasticity, in the ventral striatum of… CONTINUE READING