mTOR signaling in autophagy regulation in the kidney.

  title={mTOR signaling in autophagy regulation in the kidney.},
  author={Ken Inoki},
  journal={Seminars in nephrology},
  volume={34 1},
Cells possess adaptive biosynthetic systems to maintain cellular energy levels for survival under adverse environmental conditions. Autophagy is an evolutionarily conserved cellular catabolic process that breaks down and recycles cytosolic material including macromolecules and organelles through lysosomal degradation. This catabolic process, represented by macroautophagy, is induced by a variety of cellular stresses such as nutrient starvation, which causes a shortage of cellular energy for… CONTINUE READING


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