mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.

@article{Matsumoto2009mTORSA,
  title={mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.},
  author={Kazuko Matsumoto and Tokuzo Arao and Kaoru Tanaka and Hiroyasu Kaneda and Kanae Kudo and Yoshihiko Fujita and Daisuke Tamura and Keiichi Aomatsu and Tomohide Tamura and Yasuhide Yamada and Nagahiro George Saijo and Kazuto Nishio},
  journal={Cancer research},
  year={2009},
  volume={69 18},
  pages={7160-4}
}
The underlying mechanism regulating the expression of the cancer stem cell/tumor-initiating cell marker CD133/prominin-1 in cancer cells remains largely unclear, although knowledge of this mechanism would likely provide important biological information regarding cancer stem cells. Here, we found that the inhibition of mTOR signaling up-regulated CD133 expression at both the mRNA and protein levels in a CD133-overexpressing cancer cell line. This effect was canceled by a rapamycin-competitor… CONTINUE READING