mTOR regulates brain morphogenesis by mediating GSK3 signaling

@inproceedings{Ka2014mTORRB,
  title={mTOR regulates brain morphogenesis by mediating GSK3 signaling},
  author={Minhan Ka and Gianluigi Condorelli and James R Woodgett and Woo-Yang Kim},
  booktitle={Development},
  year={2014}
}
Balanced control of neural progenitor maintenance and neuron production is crucial in establishing functional neural circuits during brain development, and abnormalities in this process are implicated in many neurological diseases. However, the regulatory mechanisms of neural progenitor homeostasis remain poorly understood. Here, we show that mammalian target of rapamycin (mTOR) is required for maintaining neural progenitor pools and plays a key role in mediating glycogen synthase kinase 3… CONTINUE READING

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References

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ANestin - cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors

  • H. Liang, S. andGhashghaei Hippenmeyer, T. H.
  • Biol . Open
  • 2012
1 Excerpt

ANestin-cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors.Biol

  • H. Liang, Hippenmeyer, H.T.S. andGhashghaei
  • 2012
1 Excerpt

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