mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.

@article{Dai2011mTORPI,
  title={mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.},
  author={Ning Dai and Joseph Rapley and Matthew Angel and Mehmet Fatih Yanik and Michael D Blower and Joseph Avruch},
  journal={Genes & development},
  year={2011},
  volume={25 11},
  pages={1159-72}
}
Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an oncofetal RNA-binding protein. IMP2 is doubly phosphorylated… CONTINUE READING