mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis.

@article{Citraro2016mTORPI,
  title={mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis.},
  author={R. Citraro and Antonio Leo and Andrew Constanti and Emilio Russo and Giovambattista De Sarro},
  journal={Pharmacological research},
  year={2016},
  volume={107},
  pages={333-343}
}
Several preclinical and some clinical studies have revealed that the mammalian target of rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy syndromes. Excessive activation of mTOR signaling, as a consequence of loss-of-function of genes encoding for tuberous sclerosis complex (TSC) 1 and 2, is linked to the development of… CONTINUE READING