mTOR inhibition improves immune function in the elderly

@article{Mannick2014mTORII,
  title={mTOR inhibition improves immune function in the elderly},
  author={J. Mannick and G. del Giudice and M. Lattanzi and N. Valiante and J. Praestgaard and B. Huang and M. Lonetto and H. Maecker and J. Kovarik and S. Carson and D. Glass and L. Klickstein},
  journal={Science Translational Medicine},
  year={2014},
  volume={6},
  pages={268ra179 - 268ra179}
}
mTOR inhibition by RAD001 improves immune responses in elderly volunteers receiving an influenza vaccination. mTOR and Human Aging Inhibition of mTOR signaling extends life span and delays the onset of aging-related diseases in all species studied to date. These findings suggest that the mTOR pathway regulates aging. However, it is unknown if mTOR inhibition has beneficial effects on aging in humans. To begin to address this question, Mannick et al. evaluated the effects of the mTOR inhibitor… Expand
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