mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators.

@article{Nader2005mTORFI,
  title={mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators.},
  author={Gustavo A. Nader and Thomas J. McLoughlin and Karyn A Esser},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={289 6},
  pages={C1457-65}
}
The purpose of this study was to identify the potential downstream functions associated with mammalian target of rapamycin (mTOR) signaling during myotube hypertrophy. Terminally differentiated myotubes were serum stimulated for 3, 6, 12, 24, and 48 h. This treatment resulted in significant myotube hypertrophy (protein/DNA) and increased RNA content (RNA/DNA) with no changes in DNA content or indices of cell proliferation. During myotube hypertrophy, the increase in RNA content was accompanied… CONTINUE READING