mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

  title={mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.},
  author={Demetrios Kalaitzidis and Stephen M. Sykes and Zhu Wang and Natalie Punt and Yuefeng Tang and Christine Ragu and Amit U Sinha and Steven W Lane and Amanda L. Souza and Clary B Clish and Dimitrios Anastasiou and Dwight Gary Gilliland and David T Scadden and David A. Guertin and Scott A. Armstrong},
  journal={Cell stem cell},
  volume={11 3},
The mechanistic target of rapamycin (mTOR) pathway serves as a key sensor of cellular-energetic state and functions to maintain tissue homeostasis. Hyperactivation of the mTOR pathway impairs hematopoietic stem cell (HSC) function and is associated with leukemogenesis. However, the roles of the unique mTOR complexes (mTORCs) in hematopoiesis and leukemogenesis have not been adequately elucidated. We deleted the mTORC1 component, regulatory-associated protein of mTOR (Raptor), in mouse HSCs and… CONTINUE READING
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