mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy.

@article{Song2010mTORAT,
  title={mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy.},
  author={Xiaoxiao Song and Yoichiro Kusakari and Chun-Yang Xiao and Stuart Duncan Kinsella and Michael A Rosenberg and Marielle Scherrer-Crosbie and Kenta Hara and Anthony Rosenzweig and Takashi Matsui},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={299 6},
  pages={C1256-66}
}
Previous studies have suggested that inhibition of the mammalian target of rapamycin (mTOR) by rapamycin suppresses myocardial hypertrophy. However, the role of mTOR in the progression of cardiac dysfunction in pathological hypertrophy has not been fully defined. Interestingly, recent reports indicate that the inflammatory response, which plays an important role in the development of heart failure, is enhanced by rapamycin under certain conditions. Our aim in this study was to determine the… CONTINUE READING
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