mTOR and metabolic regulation of conventional and regulatory T cells.

  title={mTOR and metabolic regulation of conventional and regulatory T cells.},
  author={Chaohong Liu and Nicole M. Chapman and Peer W F Karmaus and Hu Zeng and Hongbo Chi},
  journal={Journal of leukocyte biology},
  volume={97 5},
mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and Tregs In this review, we discuss the regulation of mTOR signaling in T cells and the functional impacts of mTOR and metabolic pathways on T cell-mediated immune responses, with a particular focus on… CONTINUE READING

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