mTOR and lymphocyte metabolism.

@article{Zeng2013mTORAL,
  title={mTOR and lymphocyte metabolism.},
  author={Hu Zeng and Hongbo Chi},
  journal={Current opinion in immunology},
  year={2013},
  volume={25 3},
  pages={
          347-55
        }
}
Upon antigen engagement and proper co-stimulation, naïve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures. Emerging evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immune signals and metabolic cues to direct lymphocyte proliferation… CONTINUE READING

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