mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury.

@article{Liang2013mTORAI,
  title={mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury.},
  author={Lingli Liang and Bo Tao and Longchang Fan and Myron Yaster and Yi Zhang and Yuan-Xiang Tao},
  journal={Brain research},
  year={2013},
  volume={1513},
  pages={17-25}
}
Protein translation controlled through activation of mammalian target of rapamycin (mTOR) participates in many physiological and pathological processes. However, whether such activation is required for chronic pain is still unknown. Here, we examined activation of the mTOR signaling pathway during complete Freund's adjuvant (CFA)-induced chronic inflammatory pain and L5 spinal nerve ligation (SNL)-induced neuropathic pain in rats. Western blot analysis showed significantly increased levels of… CONTINUE READING