mTOR: on target for novel therapeutic strategies in the nervous system.

@article{Maiese2013mTOROT,
  title={mTOR: on target for novel therapeutic strategies in the nervous system.},
  author={Kenneth Maiese and Zhao Zhong Chong and Yan Chen Shang and Shaohui Wang},
  journal={Trends in molecular medicine},
  year={2013},
  volume={19 1},
  pages={51-60}
}
The mammalian target of rapamycin (mTOR), the key component of the protein complexes mTORC1 and mTORC2, plays a critical role in cellular development, tissue regeneration, and repair. mTOR signaling can govern not only stem cell development and quiescence but also cell death during apoptosis or autophagy. Recent studies highlight the importance of both traditional and newly recognized interactors of mTOR, such as p70S6K, 4EBP1, GSK-3β, REDD1/RTP801, TSC1/TSC2, growth factors, wingless, and… CONTINUE READING