mTOR/p70S6k signalling alteration by Aβ exposure as well as in APP‐PS1 transgenic models and in patients with Alzheimer's disease

@article{LafayChebassier2005mTORp70S6kSA,
  title={mTOR/p70S6k signalling alteration by A$\beta$ exposure as well as in APP‐PS1 transgenic models and in patients with Alzheimer's disease},
  author={C. Lafay-Chebassier and M. Paccalin and G. Page and St{\'e}phanie Barc-Pain and M. P{\'e}rault-Pochat and R. Gil and L. Pradier and J. Hugon},
  journal={Journal of Neurochemistry},
  year={2005},
  volume={94}
}
In Alzheimer's disease, neuropathological hallmarks include the accumulation of β‐amyloid peptides (Aβ) in senile plaques, phosphorylated tau in neurofibrillary tangles and neuronal death. Aβ is the major aetiological agent according to the amyloid cascade hypothesis. Translational control includes phosphorylation of the kinases mammalian target of rapamycin (mTOR) and p70S6k which modulate cell growth, proliferation and autophagy. It is mainly part of an anti‐apoptotic cellular signalling. In… Expand
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